Leigh Halfpenny was released by Wales on Wednesday to play for the Scarlets in Italy
this weekend, making it more unlikely he lines up against England.
The full-back, 30, has just returned from almost three months off with lingering concussion issues having been knocked out for Wales against Australia in November.
Halfpenny trained with Wales on Wednesday but as Sportsmail
reported on Tuesday they do not want to rush the two-time Lion back to soon, and on Tuesday decided to send him back to the Scarlets.
The regional side play Treviso in Italy this Saturday.
Meanwhile Shaun Edwards warned England they would up their level on Saturday week in the crunch Six Nations match.
'We don't want to get pumped up too soon,' he said.
'But we didn't do a good job of that this morning because there was fire and brimstone in the training session.
'We feel we can player better than we have done in the last two games. We don't feel we've achieved the level of performance we showed in the autumn.
'Hopefully our best level of rugby is yet to come in this Six Nations. We want to improve, get better, and we know we'll have to do that to beat England.'
Rhys Patchell and Steff Evans are also available for the Scarlets this weekend, and Seb Davies, Josh Turnbull and Jarrod Evans go back to Cardiff Blues on Thursday.